MOTS-c
Also known as Mitochondrial ORF of the 12S rRNA type-c
MOTS-c is a peptide encoded not by the cell nucleus but by mitochondrial DNA, which makes it unusual and is why it attracts research interest. It was identified in 2015. It is described in the literature as a mitochondrial-derived peptide involved in metabolic signalling.
Who has MOTS-c in stock
| Supplier | Listing | Price | Per mg | |
|---|---|---|---|---|
| XL PeptidesBest valueUK | MOTS-c 10mg Research Peptide | £23.99 | £2.40 | In stock, go |
| Peptides UKUK | MOTS-c 10mg | £29.95 | £3.00 | In stock, go |
| Baltic PeptidesEU and UK | MOTS-c 10mg | €39.99 | €4.00 | In stock, go |
| Certa PeptidesEU and UK | MOTS-c | €41.99 | – | In stock, go |
| PEAK_PEPTIDEInternational | MOTS-C | €49.90 | – | In stock, go |
| HiPeptidesUK | MOTS-c | £49.99 | – | In stock, go |
| True PeptidesInternational | MOTS-c | US$63.00 | – | In stock, go |
| AminoPeptidesUK | SS-31 (10mg) & MOTS-c (10mg) & NAD+ (500mg) | Mito Peptide Bundle | £124.00 | – | In stock, go |
Live stock is checked hourly at 10 suppliers. A further 7 vetted suppliers have no live feed yet, so we never show them as in stock. We earn a commission from some supplier links when you buy. It costs you nothing extra and never changes the order, which is by price per mg.
What it has been studied for
- Insulin sensitivity in mouse models
- Exercise capacity in aged mice
- AMPK pathway activation in cell studies
- Metabolic markers in early observational human work
Evidence level: Animal studies only. Results in animals or cells often fail to carry over to people.
What happened in human trials
MOTS-c itself has never been trialled in people. A modified version (CB4211) reached an early trial, where injection site reactions were the main problem.
Prohibited in drug-tested sport under the World Anti-Doping Code.
UK legal status
Not licensed as a medicine in the UK. Not approved for human use.
Handling
Lyophilised powder, reconstituted with bacteriostatic water, refrigerated once mixed. Commonly 5mg or 10mg per vial.
Questions
What makes MOTS-c unusual?
It is encoded by mitochondrial DNA rather than nuclear DNA. Mitochondria carry their own small genome, and MOTS-c is one of a handful of peptides identified as originating there.
Is there human evidence?
Very little. The published work is predominantly mouse studies and cell culture, with some observational human data on naturally occurring levels rather than administration.
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