PT-141
Also known as Bremelanotide, Vyleesi
PT-141, generic name bremelanotide, is a cyclic seven-amino-acid peptide that activates melanocortin receptors in the brain. It was developed from Melanotan II. In 2019 the US FDA approved it as Vyleesi for hypoactive sexual desire disorder in premenopausal women. It is not licensed in the UK.
Who has PT-141 in stock
| Supplier | Listing | Price | Per mg | |
|---|---|---|---|---|
| XL PeptidesBest valueUK | PT-141 10mg Research Peptide | £16.99 | £1.70 | In stock, go |
| Peptides UKUK | PT-141 10mg | £19.95 | £1.99 | In stock, go |
| AminoPeptidesUK | PT-141 (Bremelanotide) | 10mg | £21.00 | £2.10 | In stock, go |
| Baltic PeptidesEU and UK | PT-141 (Bremelanotide) 10mg | €39.99 | €4.00 | In stock, go |
| HiPeptidesUK | PT-141 | £29.99 | – | In stock, go |
| HiPeptidesUK | PT-141 Nasal Spray | £39.99 | – | In stock, go |
| Certa PeptidesEU and UK | PT-141 | €41.99 | – | In stock, go |
| True PeptidesInternational | PT-141 | US$43.00 | – | In stock, go |
| AminoPeptidesUK | Kisspeptin & PT-141 Peptide Bundle | £67.00 | – | In stock, go |
| 99 Purity PeptidesUS | PT-141 Spray | US$74.99 | – | In stock, go |
Live stock is checked hourly at 10 suppliers. A further 7 vetted suppliers have no live feed yet, so we never show them as in stock. We earn a commission from some supplier links when you buy. It costs you nothing extra and never changes the order, which is by price per mg.
What it has been studied for
- Hypoactive sexual desire disorder in premenopausal women, phase 3 RECONNECT trials
- Erectile dysfunction in men, earlier phase 2 work
- Blood pressure changes after dosing
Evidence level: Human trials. Human data exists, but read the details above before assuming it applies to you.
What happened in human trials
Licensed in the US for low desire in premenopausal women. In those trials 40% had nausea (against 1% on placebo), 20% flushing, 13% injection site reactions and 11% headache. Blood pressure rose for a few hours after each dose. Repeated daily use darkened the skin and gums in some people.
UK legal status
Not licensed as a medicine in the UK. The approved US product is prescription-only there.
Handling
Supplied as a lyophilised powder. Reconstituted with bacteriostatic water and refrigerated once mixed. Commonly 10mg per vial.
Questions
What side effects were reported in the trials?
Nausea was the most common, reported by around 40% of participants in the phase 3 trials. Flushing, headache and a temporary rise in blood pressure were also recorded, and some participants developed darkening of the skin or gums with repeated use.
Before you buy anything, run the four-question check for red flags that apply to you.